Plasma exchanges and immunosuppression for anti-complement factor H associated hemolytic uremic syndrome.

BACKGROUND Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure. CASE CHARACTERISTICS 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies. INTERVENTION Prompt initiation of plasma exchanges and immunosuppression. OUTCOME Remission of hematological and kidney functions. MESSAGE Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.